Biological Role Of Growth Factors In Periodontology: A Review Singh B, Garg A, Garg RK. Biological Role Of Growth Factors In Periodontology: A Review. J Periodontal Med Clin Pract. 2014;01: 61-70

Periodontal diseases result in destruction of periodontal tissues, including cementum, bone and periodontal ligament, with eventual loss of tooth if left untreated. Various studies and clinical investigations have resulted in improved therapies for the arrest of disease progression and regeneration of periodontal tissues. A key factor for enhancing the predictability of regenerative therapies is an understanding of cellular and molecular events required to regenerate periodontal tissues. It is now recognized that an important link, although not exact, to understanding the requirements for regeneration of tissues is to acquire knowledge as to mechanisms involved in development of tissues.During development, it is now recognized that specific growth factors and morphogens trigger differentiation of epithelial and mesenchymal derived cells during tooth formation. The importance of these growth factors for regeneration of periodontal tissues as well as the function of endogenous factors present at wound sites is currently being examined in in-vivo and in-vitro modes.